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Target
Cyclin-dependent kinase 1
Ligand
BDBM153477
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
7800±n/a nM
Citation
 Belmont, PO; Meijer, L; Cohen, P; Patin, A; Bosson, J; Goekjian, PG Tetrahydrocyclopenta[c]acridine derivatives as kinase inhibitors and biological US Patent  US8999955 Publication Date 4/7/2015 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM153477
Synonyms:
US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-tetrahydro-2H-cyclopenta[c]acridin-2-one (+ enantiomer) | US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-tetrahydro-2H-cyclopenta[c]acridin-2-one (enantiomer) | US8999955, 5-hydroxy-1-trimethylsilanyl-3,3a,4,5-tetrahydro-2H-cyclopenta[c]acridin-2-one (racemic)
Type:
Small organic molecule
Emp. Form.:
C19H21NO2Si
Mol. Mass.:
323.461
SMILES:
C[Si](C)(C)C1=C2C(CC1=O)CC(O)c1cc3ccccc3nc21 |t:4|
Structure:
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