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Target
Interleukin-1 receptor-associated kinase 1
Ligand
BDBM286306
Substrate
n/a
Meas. Tech.
IRAK1 Enzymatic Assay
IC50
550±n/a nM
Citation
 Jorand-Lebrun, C; Kulkarni, S; Crosignani, S Pyridazinone-amides derivatives US Patent  US9567320 Publication Date 2/14/2017 
Target
Name:
Interleukin-1 receptor-associated kinase 1
Synonyms:
IRAK | IRAK-1 | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK-1)
Type:
Enzyme
Mol. Mass.:
76536.81
Organism:
Homo sapiens (Human)
Description:
P51617
Residue:
712
Sequence:
MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
  
Inhibitor
Name:
BDBM286306
Synonyms:
N-(1H-benzo[d]imidazol-2-yl)-3-((3-(6-methylpyridazin-4-yl)-6-oxopyridazin-1(6H)-yl)methyl)benzamide | US9567320, Example 13
Type:
Small organic molecule
Emp. Form.:
C24H19N7O2
Mol. Mass.:
437.4534
SMILES:
Cc1cc(cnn1)-c1ccc(=O)n(Cc2cccc(c2)C(=O)Nc2nc3ccccc3[nH]2)n1
Structure:
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