Reaction Details Report a problem with these data
Target
PHD finger protein 1
Ligand
BDBM154547
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
pH
8±0
Temperature
1937.05±0 K
IC50
8.2e+4± 1.3e+4 nM
Citation
 Perfetti, MT; Baughman, BM; Dickson, BM; Mu, Y; Cui, G; Mader, P; Dong, A; Norris, JL; Rothbart, SB; Strahl, BD; Brown, PJ; Janzen, WP; Arrowsmith, CH; Mer, G; McBride, KM; James, LI; Frye, SV Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol 10:1072-81 (2015) [PubMed]  Article 
Target
Name:
PHD finger protein 1
Synonyms:
PCL1 | PHD finger protein 1 (PHF1) | PHF1 | PHF1_HUMAN
Type:
Protein
Mol. Mass.:
62133.86
Organism:
Homo sapiens (Human)
Description:
O43189
Residue:
567
Sequence:
MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGREIKKRKCLFGLHARMPPPVEPPTGDGALTSFPSGQGPGGGVSRPLGKRRRPEPEPLRRRQKGKVEELGPPSAVRNQPEPQEQRERAHLQRALQASVSPPSPSPNQSYQGSSGYNFRPTDARCLPSSPIRMFASFHPSASTAGTSGDSGPPDRSPLELHIGFPTDIPKSAPHSMTASSSSVSSPSPGLPRRSAPPSPLCRSLSPGTGGGVRGGVGYLSRGDPVRVLARRVRPDGSVQYLVEWGGGGIF
  
Inhibitor
Name:
BDBM154547
Synonyms:
3-Bromo-N-(3-(isopropylamino)propyl)benzamide (3)
Type:
Small organic molecule
Emp. Form.:
C13H19BrN2O
Mol. Mass.:
299.207
SMILES:
CC(C)NCCCNC(=O)c1cccc(Br)c1
Structure:
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