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TargetE3 ubiquitin-protein ligase (UHRF1)
LigandBDBM154550
Substrate/Competitorn/a
Meas. Tech.AlphaScreen Assay
pH8±0
Temperature1937.05±0 K
IC50>1.00e+5± 0 nM
Citation Perfetti, MTBaughman, BMDickson, BMMu, YCui, GMader, PDong, ANorris, JLRothbart, SBStrahl, BDBrown, PJJanzen, WPArrowsmith, CHMer, GMcBride, KMJames, LIFrye, SV Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol10:1072-81 (2015) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
E3 ubiquitin-protein ligase (UHRF1)
Name:E3 ubiquitin-protein ligase (UHRF1)
Synonyms:6.3.2.- | E3 ubiquitin-protein ligase UHRF1 | HuNp95 | ICBP90 | Inverted CCAAT box-binding protein of 90 kDa | NP95 | Nuclear protein 95 | Nuclear zinc finger protein Np95 | RING finger protein 106 | RNF106 | Transcription factor ICBP90 | UHRF1 | Ubiquitin-like PHD and RING finger domain-containing protein 1 | Ubiquitin-like-containing PHD and RING finger domains protein 1 | hNp95 | hUHRF1
Type:Protein
Mol. Mass.:89822.48
Organism:Homo sapiens (Human)
Description:n/a
Residue:793
Sequence:
MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFYRGKQMEDGHTLFD
YEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKSSTHGEAAAETDSR
PADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEPCSSTSRPALEE
DVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYD
AEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGSPMVDNPMRRKSGP
SCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDPPLSSVPSEDEWYC
PECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRTKECTIVPSNHYGP
IPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDHGNFFTYTG
SGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDWRSGKPVRVVRNVK
GGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEPGPWTKEGKDRIKK
LGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKWKRKSAGGGPSRAG
SPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPASGSPFQLFLSKVEE
TFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLGRSYAMQVNQPLQT
VLNQLFPGYGNGR
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BDBM154550
n/a
NameBDBM154550
Synonyms:3-Bromo-N-(3-(pyrrolidin-1-yl)propyl)benzamide (6)
TypeSmall organic molecule
Emp. Form.C14H19BrN2O
Mol. Mass.311.217
SMILESBrc1cccc(c1)C(=O)NCCCN1CCCC1
Structure
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