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Target
Isoform 4 of Lethal(3)malignant brain tumor-like protein 1 (4)
Ligand
BDBM154554
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
pH
8±0
Temperature
1663.9±0 K
IC50
>1.00e+5±n/a nM
Citation
 Perfetti, MT; Baughman, BM; Dickson, BM; Mu, Y; Cui, G; Mader, P; Dong, A; Norris, JL; Rothbart, SB; Strahl, BD; Brown, PJ; Janzen, WP; Arrowsmith, CH; Mer, G; McBride, KM; James, LI; Frye, SV Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol 10:1072-81 (2015) [PubMed]  Article 
Target
Name:
Isoform 4 of Lethal(3)malignant brain tumor-like protein 1 (4)
Synonyms:
H-l(3)mbt | H-l(3)mbt protein | KIAA0681 | L(3)mbt protein homolog | L(3)mbt-like | L3MBT | L3MBTL | L3MBTL1 | LMBL1_HUMAN | Lethal(3)malignant brain tumor-like protein 1 | Lethal(3)malignant brain tumor-like protein 1 (4) | Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
Type:
Protein
Mol. Mass.:
83871.06
Organism:
Homo sapiens (Human)
Description:
Q9Y468-4
Residue:
752
Sequence:
MRRREGHGTDSEMGQGPVRESQSSDPPALQFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNADDTLK
  
Inhibitor
Name:
BDBM154554
Synonyms:
(3-Bromophenyl)(4-(tert-butyl)piperazin-1-yl)methanone (10)
Type:
Small organic molecule
Emp. Form.:
C15H21BrN2O
Mol. Mass.:
325.244
SMILES:
CC(C)(C)N1CCN(CC1)C(=O)c1cccc(Br)c1
Structure:
Search PDB for entries with ligand similarity: