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Target
E3 ubiquitin-protein ligase UHRF1
Ligand
BDBM154563
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
pH
8±0
Temperature
844.45±0 K
IC50
>1.00e+5±n/a nM
Citation
 Perfetti, MT; Baughman, BM; Dickson, BM; Mu, Y; Cui, G; Mader, P; Dong, A; Norris, JL; Rothbart, SB; Strahl, BD; Brown, PJ; Janzen, WP; Arrowsmith, CH; Mer, G; McBride, KM; James, LI; Frye, SV Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol 10:1072-81 (2015) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase UHRF1
Synonyms:
6.3.2.- | E3 ubiquitin-protein ligase (UHRF1) | E3 ubiquitin-protein ligase UHRF1 | HuNp95 | ICBP90 | Inverted CCAAT box-binding protein of 90 kDa | NP95 | Nuclear protein 95 | Nuclear zinc finger protein Np95 | RING finger protein 106 | RNF106 | Transcription factor ICBP90 | UHRF1 | UHRF1_HUMAN | Ubiquitin-like PHD and RING finger domain-containing protein 1 | Ubiquitin-like-containing PHD and RING finger domains protein 1 | hNp95 | hUHRF1
Type:
Protein
Mol. Mass.:
89822.48
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
793
Sequence:
MWIQVRTMDGRQTHTVDSLSRLTKVEELRRKIQELFHVEPGLQRLFYRGKQMEDGHTLFDYEVRLNDTIQLLVRQSLVLPHSTKERDSELSDTDSGCCLGQSESDKSSTHGEAAAETDSRPADEDMWDETELGLYKVNEYVDARDTNMGAWFEAQVVRVTRKAPSRDEPCSSTSRPALEEDVIYHVKYDDYPENGVVQMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGSPMVDNPMRRKSGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDPPLSSVPSEDEWYCPECRNDASEVVLAGERLRESKKKAKMASATSSSQRDWGKGMACVGRTKECTIVPSNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAPINDQEGAEAKDWRSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYWPEKGKSGFLVWRYLLRRDDDEPGPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQEGGFASPRTGKGKWKRKSAGGGPSRAGSPRRTSKKTKVEPYSLTAQQSSLIREDKSNAKLWNEVLASLKDRPASGSPFQLFLSKVEETFQCICCQELVFRPITTVCQHNVCKDCLDRSFRAQVFSCPACRYDLGRSYAMQVNQPLQTVLNQLFPGYGNGR
  
Inhibitor
Name:
BDBM154563
Synonyms:
N-(3-(Tert-butylamino)propyl)-3-iodobenzamide (19)
Type:
Small organic molecule
Emp. Form.:
C14H21IN2O
Mol. Mass.:
360.2338
SMILES:
CC(C)(C)NCCCNC(=O)c1cccc(I)c1
Structure:
Search PDB for entries with ligand similarity: