Reaction Details Report a problem with these data
Target
Proteasome subunit alpha type-2
Ligand
BDBM154579
Substrate
n/a
Meas. Tech.
ChTL Inhibition Assays
pH
7.5±n/a
IC50
1.2±0.1 nM
Comments
extracted
Citation
 Trivella, DB; Pereira, AR; Stein, ML; Kasai, Y; Byrum, T; Valeriote, FA; Tantillo, DJ; Groll, M; Gerwick, WH; Moore, BS Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem Biol 21:782-91 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit alpha type-2
Synonyms:
20S proteasome | PRE8 | PRS4 | PSA2_YEAST
Type:
Protein
Mol. Mass.:
27159.02
Organism:
Saccharomyces cerevisiae s288c (Yeast)
Description:
n/a
Residue:
250
Sequence:
MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVVIATEKKSSSPLAMSETLSKVSLLTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQEATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWKATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESVEGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTSQEINDRLEAL
  
Inhibitor
Name:
BDBM154579
Synonyms:
(2S)-2-[(2S)-2-hexanamido-3-methylbutanamido]-N,N-dimethyl-N'-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]pentanediamide (3) | (2S)-N-[(4S)-2,6-dimethyl-3-oxohept-1-en-4-yl]-2-[(2S)-2-hexanamido-3-methylbutanamido]-N',N'-dimethylpentanediamide (4)
Type:
Small organic molecule
Emp. Form.:
C27H48N4O6
Mol. Mass.:
524.6932
SMILES:
CCCCCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N(C)C)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Structure:
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