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TargetAMP deaminase 1 (hAMPD1)
LigandBDBM154583
Substrate/Competitorn/a
Meas. Tech.AMPD Enzymatic Activity Assay
pH7.4±n/a
IC50 38± 0 nM
Commentsextracted
Citation Admyre, TAmrot-Fors, LAndersson, MBauer, MBjursell, MDrmota, THallen, SHartleib-Geschwindner, JLindmark, BLiu, JLöfgren, LRohman, MSelmi, NWallenius, K Inhibition of AMP deaminase activity does not improve glucose control in rodent models of insulin resistance or diabetes. Chem Biol21:1486-96 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
AMP deaminase 1 (hAMPD1)
Name:AMP deaminase 1 (hAMPD1)
Synonyms:AMP deaminase 1 | AMP deaminase 1 | AMP deaminase isoform M | Myoadenylate deaminase
Type:Protein
Mol. Mass.:90225.27
Organism:Homo sapiens (Human)
Description:n/a
Residue:780
Sequence:
MNVRIFYSVSQSPHSLLSLLFYCAILESRISATMPLFKLPAEEKQIDDAMRNFAEKVFAS
EVKDEGGRQEISPFDVDEICPISHHEMQAHIFHLETLSTSTEARRKKRFQGRKTVNLSIP
LSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYASGVTVEDFEIVCKGLYRALCIR
EKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKGEDPFRTDNLPENLGYH
LKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFL
SSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIDA
DRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASEL
RDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNR
IHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHIT
GFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTF
LFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFL
EYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSV
LQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM154583
NameBDBM154583
Synonyms:6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methyl)phenyl]pyridine-3-carboxylic acid (Compound 3)
TypeSmall organic molecule
Emp. Form.C24H21N3O2
Mol. Mass.383.4424
SMILESC[C@H](NCc1ccc(cc1)-c1ccc(cn1)C(O)=O)c1cccc2ccncc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a