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Target
Mitogen-activated protein kinase 3
Ligand
BDBM154675
Substrate
n/a
Meas. Tech.
Temperature Dependence Fluorescence Assay (TdF)
Kd
0.48±n/a nM
Citation
 Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Heterocyclic compounds as ERK inhibitors US Patent  US8999957 Publication Date 4/7/2015 
Target
Name:
Mitogen-activated protein kinase 3
Synonyms:
Erk1 | Extracellular signal-regulated kinase 1 (ERK1) | MK03_MOUSE | Mapk3 | Prkm3
Type:
Protein
Mol. Mass.:
43066.49
Organism:
Mus musculus (Mouse)
Description:
Q63844
Residue:
380
Sequence:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEGP
  
Inhibitor
Name:
BDBM154675
Synonyms:
US8999957, Table 2, Compound 12
Type:
Small organic molecule
Emp. Form.:
C28H28FN5O3
Mol. Mass.:
501.552
SMILES:
CC(=O)Nc1cc(ccc1O)-c1n[nH]c2ccc(cc12)C(=O)N[C@@H]1CCCN(Cc2ccccc2F)C1 |r|
Structure:
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