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Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM286341
Substrate
n/a
Meas. Tech.
HTRF-Based Assay
IC50
1076±n/a nM
Citation
 Bennett, DJ; Cai, J; Carswell, E; Cooke, A; Hoyt, SB; London, C; MacLean, J; Ratcliffe, P; Taylor, JA; Xiong, Y; Samanta, SK; Kulkarni, BA Triazolopyridyl compounds as aldosterone synthase inhibitors US Patent  US9567333 Publication Date 2/14/2017 
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH
Type:
Enzyme
Mol. Mass.:
57591.44
Organism:
Homo sapiens (Human)
Description:
P15538
Residue:
503
Sequence:
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
  
Inhibitor
Name:
BDBM286341
Synonyms:
4-(7-fluoro-[1,2,4] triazolo[1,5-a]pyridin-2- yl)isoquinoline | US9567333, 20
Type:
Small organic molecule
Emp. Form.:
C15H9FN4
Mol. Mass.:
264.2572
SMILES:
Fc1ccn2nc(nc2c1)-c1cncc2ccccc12
Structure:
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