Reaction Details
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Glycogen synthase kinase-3 beta
Ligand
BDBM155237
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
18.4±n/a nM
Comments
extracted
Citation
Nakayama, K; Sakai, D; Watanabe, K; Kohara, T; Aritomo, K Pyrimidone derivatives US Patent US9006232 Publication Date 4/14/2015 More Info.:
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
Glycogen synthase kinase-3 beta (GSK3beta) | Tau protein kinase 1 (TPK1)
Type:
Protein
Mol. Mass.:
46641.23
Organism:
Bos taurus (cattle)
Description:
A0A059UE90
Residue:
419
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPSNTTAASDANAGDRGQTNNAASASASDS
Inhibitor
Name:
BDBM155237
Synonyms:
US9006232, 2.205
Type:
Small organic molecule
Emp. Form.:
C21H20F2N4O2
Mol. Mass.:
398.4059
SMILES:
Cn1c(OC[C@@H]2CCCN2c2ccc(F)cc2)nc(cc1=O)-c1ccncc1F |r|
Structure:
