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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM155349
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
pH
5.5±n/a
IC50
0.7±n/a nM
Comments
extracted
Citation
 Debenham, JS; Jiang, J; Madsen-Duggan, CB; Shen, D Prolylcarboxypeptidase inhibitors US Patent  US9006268 Publication Date 4/14/2015 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM155349
Synonyms:
US9006268, 21
Type:
Small organic molecule
Emp. Form.:
C26H26ClN5
Mol. Mass.:
443.971
SMILES:
Clc1ccc(cc1)-c1nc(c([nH]1)C1CCN(CCc2ccccc2)CC1)-c1ncccn1
Structure:
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