Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM155503
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
8±n/a
IC50
314±n/a nM
Comments
extracted
Citation
 Thunuguntla, SS; Subramanya, H; Kunnam, SR; Sanivaru Vijay, SR; Bingi, C; Kusanur, R; Schwarz, M; Arlt, M Dihydroorotate dehydrogenase inhibitors US Patent  US9006454 Publication Date 4/14/2015 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM155503
Synonyms:
US9006454, I145
Type:
Small organic molecule
Emp. Form.:
C21H10F6N2O2
Mol. Mass.:
436.3067
SMILES:
Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2ccc(F)c(F)c2)c(F)c1F
Structure:
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