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Target
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Ligand
BDBM155522
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
11800±n/a nM
Citation
 Ghebremariam, YT; Cooke, JP Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof US Patent  US9011882 Publication Date 4/21/2015 
Target
Name:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Synonyms:
DDAH | DDAH1 | DDAH1_HUMAN | Dimethylarginine dimethylaminohydrolase (DDAH-1) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) E78A | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L271G | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L30A | Dimethylarginine dimethylaminohydrolase 1 (DDAH1) | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Type:
Protein
Mol. Mass.:
31116.90
Organism:
Homo sapiens (Human)
Description:
O94760
Residue:
285
Sequence:
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
  
Inhibitor
Name:
BDBM155522
Synonyms:
US9011882, Table 1, Compound 17
Type:
Small organic molecule
Emp. Form.:
C18H23N3O2S
Mol. Mass.:
345.459
SMILES:
Cc1cc(C)c2c(n1)sn(CC(=O)NCCC1=CCCCC1)c2=O |t:17|
Structure:
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