Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM287100
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
56.7±n/a nM
Comments
extracted
Citation
 Cuberes-Altisent, MR; Corbera-Arjona, J; Diaz-Fernandez, JL; Almansa-Rosales, C Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands US Patent  US9567338 Publication Date 2/14/2017 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM287100
Synonyms:
N-(1-(2- (Diisopropylamino)ethyl)- 1H-pyrazolo[3,4- d]pyrimidin-4-yl)-1- adamantylcarboxamide maleate | US9567338, 18
Type:
Small organic molecule
Emp. Form.:
C24H36N6O
Mol. Mass.:
424.5822
SMILES:
CC(C)N(CCn1ncc2c(NC(=O)C34CC5CC(CC(C5)C3)C4)ncnc12)C(C)C |TLB:21:20:23:17.16.15,THB:19:20:23.18.17:15|
Structure:
Search PDB for entries with ligand similarity: