Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM287115
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
61.9±n/a nM
Comments
extracted
Citation
 Cuberes-Altisent, MR; Corbera-Arjona, J; Diaz-Fernandez, JL; Almansa-Rosales, C Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands US Patent  US9567338 Publication Date 2/14/2017 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM287115
Synonyms:
N-(1-(4-(azepan-1- yl)butyl)-1H-pyrazolo[3,4- d]pyrimidin-4-yl)pivalamide maleate | US9567338, 41
Type:
Small organic molecule
Emp. Form.:
C20H32N6O
Mol. Mass.:
372.5077
SMILES:
CC(C)(C)C(=O)Nc1ncnc2n(CCCCN3CCCCCC3)ncc12
Structure:
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