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TargetApoptosis regulator Bcl-2
LigandBDBM156380
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization
IC50 0.5±n/a nM
Citation Diebold, RBGero, TGrover, PHuang, SIoannidis, SOgoe, CASaeh, JC Chemical compounds US Patent US9018381 Publication Date 4/28/2015
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM156380
NameBDBM156380
Synonyms:US9018381, 4 | US9248140, 4
TypeSmall organic molecule
Emp. Form.C46H50ClF3N4O7S3
Mol. Mass.959.555
SMILESCCN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@@H](O)c1ccccc1-c1ccc(Cl)cc1 |r|
Structure
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