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TargetApoptosis regulator Bcl-2
LigandBDBM156399
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization
IC50 0.6±n/a nM
Citation Diebold, RBGero, TGrover, PHuang, SIoannidis, SOgoe, CASaeh, JC Chemical compounds US Patent US9018381 Publication Date 4/28/2015
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM156399
NameBDBM156399
Synonyms:US9018381, 22 | US9248140, 22
TypeSmall organic molecule
Emp. Form.C47H50ClF3N4O8S3
Mol. Mass.987.565
SMILESOC[C@H]1CN(CC[C@H](CSc2ccccc2)Nc2ccc(cc2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c2ccc(cc2)N2CCC(CC2)[C@@H](O)c2ccccc2-c2ccc(Cl)cc2)CCO1 |r|
Structure
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