Reaction Details Report a problem with these data
Target
Androgen receptor
Ligand
BDBM143710
Substrate
n/a
Meas. Tech.
Androgen Receptor Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
9.20±2.00 nM
Comments
extracted
Citation
 Labrie, F; Singh, SM; Labrecque, R; Ciobanu, LC Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety US Patent  US9682960 Publication Date 6/20/2017 
Target
Name:
Androgen receptor
Synonyms:
ANDR_MOUSE | Ar | Nr3c4
Type:
PROTEIN
Mol. Mass.:
98196.62
Organism:
Mus musculus
Description:
ChEMBL_945930
Residue:
899
Sequence:
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAANIAPPGACLQQRQETSPRRRRRQQHTEDGSPQAHIRGPTGYLALEEEQQPSQQQAASEGHPESSCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILNEAGTMQLLQQQQQQQQHQQQHQQHQQQQEVISEGSSARAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLPECKGLPLDEGPGKSTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGALDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYGSAWAAAAAQCRYGDLGSLHGGSVAGPSTGSPPATTSSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLTSQESDYSASEVWYPGGVVNRVPYPSPNCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSNAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
  
Inhibitor
Name:
BDBM143710
Synonyms:
US9682960, EM-9156 | US9682960, EM-9288
Type:
Small organic molecule
Emp. Form.:
C26H22Cl2N4O4
Mol. Mass.:
525.383
SMILES:
CC1(C)N(CCCOc2ccc(cc2Cl)-c2cc[n+]([O-])cc2)C(=O)N(C1=O)c1ccc(C#N)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: