Reaction Details Report a problem with these data
Target
Androgen receptor
Ligand
BDBM148298
Substrate
n/a
Meas. Tech.
Androgen Receptor Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
133±n/a nM
Comments
extracted
Citation
 Labrie, F; Singh, SM; Labrecque, R; Ciobanu, LC Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety US Patent  US9682960 Publication Date 6/20/2017 
Target
Name:
Androgen receptor
Synonyms:
ANDR_MOUSE | Ar | Nr3c4
Type:
PROTEIN
Mol. Mass.:
98196.62
Organism:
Mus musculus
Description:
ChEMBL_945930
Residue:
899
Sequence:
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAANIAPPGACLQQRQETSPRRRRRQQHTEDGSPQAHIRGPTGYLALEEEQQPSQQQAASEGHPESSCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILNEAGTMQLLQQQQQQQQHQQQHQQHQQQQEVISEGSSARAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLPECKGLPLDEGPGKSTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGALDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYGSAWAAAAAQCRYGDLGSLHGGSVAGPSTGSPPATTSSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLTSQESDYSASEVWYPGGVVNRVPYPSPNCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSNAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
  
Inhibitor
Name:
BDBM148298
Synonyms:
US9682960, EM-8887
Type:
Small organic molecule
Emp. Form.:
C27H24Cl2N4O2S
Mol. Mass.:
539.476
SMILES:
Cc1c(Cl)c(ccc1N1C(=O)C(C)(C)N(CCCOc2ccc(c(Cl)c2)-c2ccncc2)C1=S)C#N
Structure:
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