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Target
Mitogen-activated protein kinase kinase kinase 14
Ligand
BDBM158794
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.2±n/a
Ki
0.2±n/a nM
Comments
extracted
Citation
 Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent  US9034866 Publication Date 5/19/2015 
Target
Name:
Mitogen-activated protein kinase kinase kinase 14
Synonyms:
HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK
Type:
Protein
Mol. Mass.:
104059.50
Organism:
Homo sapiens (Human)
Description:
Q99558
Residue:
947
Sequence:
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILNDVITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNNVAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQEDESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVWKLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPHLSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFSLVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
  
Inhibitor
Name:
BDBM158794
Synonyms:
US9034866, 269
Type:
Small organic molecule
Emp. Form.:
C22H19FN4O3
Mol. Mass.:
406.4097
SMILES:
Cc1cc(no1)[C@](C)(O)C#Cc1cc2-c3nc([nH]c3C3CC(C3)c2cc1F)C(N)=O |r,wU:6.7,wD:6.8,(6.29,5.03,;5.52,3.69,;5.99,2.23,;4.75,1.32,;3.5,2.23,;3.98,3.69,;4.75,-.22,;5.15,-1.7,;6.08,-.99,;3.41,-.99,;2.08,-1.76,;.75,-2.53,;-.59,-1.76,;-1.92,-2.53,;-3.12,-1.57,;-2.99,-.03,;-4.4,.57,;-5.42,-.59,;-4.63,-1.91,;-5.29,-3.3,;-4.63,-4.68,;-3.12,-5.03,;-3.68,-3.61,;-1.92,-4.07,;-.59,-4.84,;.75,-4.07,;2.08,-4.84,;-4.8,2.06,;-3.71,3.15,;-6.29,2.46,)|
Structure:
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