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Reaction Details
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TargetMelanocortin receptor 4
LigandBDBM160178
Substrate/Competitorn/a
Meas. Tech.Competitive Inhibition Assay
pH7.5±n/a
Temperature310.15±n/a K
Ki 0.45±n/a nM
Commentsextracted
Citation Dodd, JHShi, YYang, W Melanocortin receptor-specific peptides US Patent US9040663 Publication Date 5/26/2015
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM160178
NameBDBM160178
Synonyms:US9040663, 24
TypeSmall organic molecule
Emp. Form.C48H70N18O11
Mol. Mass.1075.1834
SMILESCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(cc2)[N+]([O-])=O)NC(=O)[C@H](CCN)NC1=O)C(N)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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