Reaction Details Report a problem with these data
Target
Pro-glucagon
Ligand
BDBM160577
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
38±n/a nM
Comments
extracted
Citation
 Chakravarty, D; Greco, M; Shook, B; Xu, G; Zhang, R Biphenyl derivatives useful as glucagon receptor antagonists US Patent  US9045389 Publication Date 6/2/2015 
Target
Name:
Pro-glucagon
Synonyms:
GCG | GLUC_HUMAN | Glucagon | Glucagon receptor (GCGR)
Type:
Enzyme
Mol. Mass.:
20907.95
Organism:
Homo sapiens (Human)
Description:
P01275
Residue:
180
Sequence:
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK
  
Inhibitor
Name:
BDBM160577
Synonyms:
US9045389, 9
Type:
Small organic molecule
Emp. Form.:
C29H24FN3O5
Mol. Mass.:
513.5164
SMILES:
OC(=O)CCNC(=O)c1ccc(cc1)-c1ccccc1CNc1ccc(cc1)-c1ccc(F)c(c1)[N+]([O-])=O
Structure:
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