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TargetSUMO-activating enzyme
LigandBDBM47952
Substrate/Competitorn/a
Meas. Tech.Biochemical Assay
IC50 500±n/a nM
Citation Chen, YLi, YDivlianska, DBobkova, ERoth, GPu, JKhan, P Inhibition of small ubiquitin-like modifier enzymes with substituted pyrrolo[2,3-b]quinoxalines US Patent US9045483 Publication Date 6/2/2015
More Info.:Get all data from this article,  Assay Method
 
SUMO-activating enzyme
Name:SUMO-activating enzyme
Synonyms:SUMO E1
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 977623
Components:This complex has 2 components.
Component 1
Name:SUMO-activating enzyme subunit 2 (SAE2)
Synonyms:6.3.2.- | Anthracycline-associated resistance ARX | SAE2 | SUMO-activating enzyme subunit 2 | UBA2 | UBLE1B | Ubiquitin-like 1-activating enzyme E1B | Ubiquitin-like modifier-activating enzyme 2
Type:Enzyme
Mol. Mass.:71206.17
Organism:Homo sapiens (Human)
Description:Q9UBT2
Residue:640
Sequence:
MALSRGLPRELAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQ
FLFQKKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRA
ARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPS
EPIHCIVWAKYLFNQLFGEEDADQEVSPDRADPEAAWEPTEAEARARASNEDGDIKRIST
KEWAKSTGYDPVKLFTKLFKDDIRYLLTMDKLWRKRKPPVPLDWAEVQSQGEETNASDQQ
NEPQLGLKDQQVLDVKSYARLFSKSIETLRVHLAEKGDGAELIWDKDDPSAMDFVTSAAN
LRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQCRTIFLNK
QPNPRKKLLVPCALDPPNPNCYVCASKPEVTVRLNVHKVTVLTLQDKIVKEKFAMVAPDV
QIEDGKGTILISSEEGETEANNHKKLSEFGIRNGSRLQADDFLQDYTLLINILHSEDLGK
DVEFEVVGDAPEKVGPKQAEDAAKSITNGSDDGAQPSTSTAQEQDDVLIVDSDEEDSSNN
ADVSEEERSRKRKLDEKENLSAKRSRIEQKEELDDVIALD
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Component 2
Name:SUMO1 activating enzyme subunit 1
Synonyms:SUMO-activating enzyme subunit 1 (SAE1)
Type:Enzyme Catalytic Domain
Mol. Mass.:38440.84
Organism:Homo sapiens
Description:gi_17390638
Residue:346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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BDBM47952
NameBDBM47952
Synonyms:MLS000588669 | N-(1-allyl-3-tosyl-pyrrolo[3,2-b]quinoxalin-2-yl)benzenesulfonamide | N-[1-Allyl-3-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-yl]-benzenesulfonamide | N-[3-(4-methylphenyl)sulfonyl-1-prop-2-enyl-2-pyrrolo[3,2-b]quinoxalinyl]benzenesulfonamide | N-[3-(4-methylphenyl)sulfonyl-1-prop-2-enyl-pyrrolo[3,2-b]quinoxalin-2-yl]benzenesulfonamide | N-[3-(4-methylphenyl)sulfonyl-1-prop-2-enylpyrrolo[3,2-b]quinoxalin-2-yl]benzenesulfonamide | SMR000212322 | US9045483, 12 | cid_1942142
TypeSmall organic molecule
Emp. Form.C26H22N4O4S2
Mol. Mass.518.607
SMILESCc1ccc(cc1)S(=O)(=O)c1c(NS(=O)(=O)c2ccccc2)n(CC=C)c2nc3ccccc3nc12
Structure
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n/a