Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM161552
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
pH
7.4±n/a
IC50
21.1±n/a nM
Comments
extracted
Citation
 Le Tiran, A; Le Diguarher, T; Starck, J; Henlin, J; Guillouzic, A; De Nanteuil, G; Geneste, O; Fejes, I; Tatai, J; Nyerges, M; Davidson, JE; Murray, JB; Chen, I; Durand, D Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9108983 Publication Date 8/18/2015 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM161552
Synonyms:
US9108983, Example 101
Type:
Small organic molecule
Emp. Form.:
C39H41FN6O5
Mol. Mass.:
692.7784
SMILES:
COc1cc(-c2cc(C(=O)N(c3cnn(C)c3)c3ccc(O)cc3)c(C)n2C)c(cc1F)C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1
Structure:
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