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TargetApoptosis regulator Bcl-2
LigandBDBM161571
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarisation Assay
pH7.4±n/a
IC50 2.6±n/a nM
Commentsextracted
Citation Le Tiran, ALe Diguarher, TStarck, JHenlin, JGuillouzic, ADe Nanteuil, GGeneste, OFejes, ITatai, JNyerges, MDavidson, JEMurray, JBChen, IDurand, D Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them US Patent US9108983 Publication Date 8/18/2015
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM161571
NameBDBM161571
Synonyms:US9108983, Example 386 | US9108983, Example 449
TypeSmall organic molecule
Emp. Form.C41H41ClN6O4
Mol. Mass.717.255
SMILESCc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Structure
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