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TargetApoptosis regulator Bcl-2
LigandBDBM161639
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarisation Assay
pH7.4±n/a
IC50 2.5±n/a nM
Commentsextracted
Citation Le Tiran, ALe Diguarher, TStarck, JHenlin, JGuillouzic, ADe Nanteuil, GGeneste, OFejes, ITatai, JNyerges, MDavidson, JEMurray, JBChen, IDurand, D Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them US Patent US9108983 Publication Date 8/18/2015
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM161639
NameBDBM161639
Synonyms:US9108983, Example 459
TypeSmall organic molecule
Emp. Form.C42H43ClN6O4
Mol. Mass.731.282
SMILESCCn1c(C)c(cc1C#N)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Structure
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