Reaction Details
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D-amino-acid oxidase
Ligand
BDBM287774
Substrate
n/a
Meas. Tech.
In Vitro DAAO Enzyme Assay
pH
7.4±n/a
IC50
2800±n/a nM
Comments
extracted
Citation
Cockcroft, XF; Farnaby, W; Kinsella, N; Merchant, K; Miller, D Pyrimidinone compounds and their use US Patent US10085986 Publication Date 10/2/2018 More Info.:
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
Inhibitor
Name:
BDBM287774
Synonyms:
US10085986, Example 30
Type:
Small organic molecule
Emp. Form.:
C11H10N2O2S
Mol. Mass.:
234.274
SMILES:
Oc1cnc(CSc2ccccc2)[nH]c1=O
Structure:
