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Target
Histone deacetylase 3/Nuclear receptor corepressor 2 [395-498]
Ligand
BDBM163633
Substrate
n/a
Meas. Tech.
HDAC Activity Assays
IC50
6.98e+3±n/a nM
Citation
 Wang, Y; Stowe, RL; Pinello, CE; Tian, G; Madoux, F; Li, D; Zhao, LY; Li, JL; Wang, Y; Wang, Y; Ma, H; Hodder, P; Roush, WR; Liao, D Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol 22:273-84 (2015) [PubMed]  Article 
Target
Name:
Histone deacetylase 3/Nuclear receptor corepressor 2 [395-498]
Synonyms:
HDAC3/NCOR2
Type:
Protein
Mol. Mass.:
n/a
Description:
BPS Bioscience
Components:
This complex has 2 components.
Component 1
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Component 2
Name:
Nuclear receptor corepressor 2 [395-498]
Synonyms:
CTG26 | Deacetylase activation domain (NCOR2) | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2
Type:
Protein
Mol. Mass.:
12719.17
Organism:
Homo sapiens (Human)
Description:
Deacetylase activation domain of human NCOR2 (395-498aa)
Residue:
104
Sequence:
IPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQ
  
Inhibitor
Name:
BDBM163633
Synonyms:
SR-3364 | US10807944, Compound RLS2-256 | US11731934, Compound RLS2-256
Type:
Small organic molecule
Emp. Form.:
C13H17BrN2O
Mol. Mass.:
297.191
SMILES:
Brc1ccc(cc1)C(=O)NNCC1CCCC1
Structure:
Search PDB for entries with ligand similarity: