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TargetLeucyl-tRNA synthetase K510A mutant (K510A)
LigandBDBM163674
Substrate/Competitorn/a
Meas. Tech.Isothermal Titration Calorimetry (ITC)
pH8±0
Temperature298.15±0 K
Kd 4.6e+4± 6e+3 nM
Citation Zhao, HPalencia, ASeiradake, EGhaemi, ZCusack, SLuthey-Schulten, ZMartinis, S Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism. ACS Chem Biol10:2277-85 (2015) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Leucyl-tRNA synthetase K510A mutant (K510A)
Name:Leucyl-tRNA synthetase K510A mutant (K510A)
Synonyms:n/a
Type:Protein
Mol. Mass.:125339.73
Organism:Candida albicans (Ascomycetes)
Description:n/a
Residue:1097
Sequence:
MSGPVTFEKTFRRDALIDIEKKYQKVWAEEKVFEVDAPTFEECPIEDVEQVQEAHPKFFA
TMAYPYMNGVLHAGHAFTLSKVEFATGFQRMNGKRALFPLGFHCTGMPIKAAADKIKREV
ELFGSDFSKAPIDDEDAVESQQPAKTETKREDVTKFSSKKSKAAAKQGRAKFQYEIMMQL
GIPREEVAKFANTDYWLEFFPPLCQKDVTAFGARVDWRRSMITTDANPYYDAFVRWQINR
LRDVGKIKFGERYTIYSEKDGQACLDHDRQSGEGVGPQEYVGIKIRLTDVAPQAQELFKK
ENLDVKENKVYLVAATLRPETMYGQTCCFVSPKIDYGVFDAGNGDYFITTERAFKNMSFQ
NLTPKRGYYKPLFIINGKTLIGSRIDAPYAVNKNLRVLPMETVLATKGTGVVTCVPSDSP
DDFVTTRDLANKPEYYGIEKDWVQTDIVPIVHTEKYGDKCAEFLVNDLKIQSPKDSVQLA
NAKELAYKEGFYNGTMLIGKYKGDKVEDAAPKVKQDLIDEGLAFVYNEPESQVISRSGDD
CCVSLEDQWYIDYGEEAWLGEALECLKNMETYSKETRHGFEGVLAWMKNWAVTRKFGLGT
KLPWDPQYLVESLSDSTVYMAYYTIDRFLHSDYYGKKAGKFDIKPEQMTDEVFDYIFTRR
DDVETDIPKEQLKEMRREFEYFYPLDVRVSGKDLIPNHLTFFIYTHVALFPKRFWPRGVR
ANGHLLLNNAKMSKSTGNFMTLEQIIEKFGADASRIAMADAGDTVEDANFDEANANAAIL
RLTTLKDWCEEEVKNQDKLRTGDYDSFFDAAFENEMNDLIEKTYQQYTLSNYKQALKSGL
FDFQIARDIYRESVNTTGIGMHKDLVLKYIEYQALMLAPIAPHFAEYLYREVLGKNGSVQ
TSKFPRASKPVSKAILDASEYVRSLTRSIREAEGQALKKKKGKSDVDGSKPTSLTVLVSN
TFPEWQDNYIELVRELFEQNKLDDNNVIRQKVGKDMKRGMPYIHQIKTRLATEDADTVFN
RKLTFDEIDTLKNVVEIVKNAPYSLKVEKLEILSFNNGETKGKNIISGEDNIELNFKGKI
MENAVPGEPGIFIKNVE
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  Blast E-value cutoff:
BDBM163674
NameBDBM163674
Synonyms:AN2690-AMP
TypeSmall organic molecule
Emp. Form.C18H18BFN5O4
Mol. Mass.398.177
SMILESCC[C@H]1O[C@H]([C@H]2O[B-]3(OCc4cc(F)ccc34)OC12)n1cnc2c(N)ncnc12 |r|
Structure
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n/a