Reaction Details Report a problem with these data
Target
Lipopolysaccharide-induced tumor necrosis factor-alpha factor
Ligand
BDBM235383
Substrate
n/a
Meas. Tech.
TNF inhibition assay
IC50
2.00±n/a nM
Citation
 Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors US Patent  US10085990 Publication Date 10/2/2018 
Target
Name:
Lipopolysaccharide-induced tumor necrosis factor-alpha factor
Synonyms:
LITAF | LITAF_HUMAN | LPS-induced TNF-alpha factor | PIG7 | SIMPLE | Small integral membrane protein of lysosome/late endosome | TNF-alpha | p53-induced gene 7 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17106.57
Organism:
Homo sapiens (Human)
Description:
TNF-alpha 0 HUMAN::Q99732
Residue:
161
Sequence:
MSVPGPYQAATGPSSAPSAPPSYEETVAVNSYYPTPPAPMPGPTTGLVTGPDGKGMNPPSYYTQPAPIPNNNPITVQTVYVQHPITFLDRPIQMCCPSCNKMIVSQLSYNAGALTWLSCGSLCLLGCIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL
  
Inhibitor
Name:
BDBM235383
Synonyms:
US10085990, Example 116 | US9393245, 116
Type:
Small organic molecule
Emp. Form.:
C27H27ClN4O5
Mol. Mass.:
522.98
SMILES:
COc1cccc2c1ncc1c2n([C@H]2CCN(C2)C(=O)OC(C)(C)C)c(=O)n(-c2cccc(Cl)c2)c1=O |r|
Structure:
Search PDB for entries with ligand similarity: