Reaction Details Report a problem with these data
Target
Dimer of Gag-Pol polyprotein [514-612]
Ligand
BDBM770
Substrate
Peptide Substrate
Meas. Tech.
Protease Inhibition Assay
Ki
32±n/a nM
Citation
 Thaisrivongs, S; Tomich, PK; Watenpaugh, KD; Chong, KT; Howe, WJ; Yang, CP; Strohbach, JW; Turner, SR; McGrath, JP; Bohanon, MJ Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors. J Med Chem 37:3200-4 (1994) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [514-612]
Synonyms:
HIV-2 Protease
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [514-612]
Synonyms:
HIV-2 Protease chain A | HIV-2 Protease chain B | POL_HV2RO | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10718.25
Organism:
Human immunodeficiency virus type 2
Description:
P04584[514-612]
Residue:
99
Sequence:
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGGFINTKEYKNVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
  
Component 2
Name:
Gag-Pol polyprotein [514-612]
Synonyms:
HIV-2 Protease chain A | HIV-2 Protease chain B | POL_HV2RO | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10718.25
Organism:
Human immunodeficiency virus type 2
Description:
P04584[514-612]
Residue:
99
Sequence:
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGGFINTKEYKNVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
  
Inhibitor
Name:
BDBM770
Synonyms:
4-hydroxy-6-(1-phenylbutan-2-yl)-3-(1-phenylpropyl)-2H-pyran-2-one | CHEMBL22164 | U-96988
Type:
Small organic molecule
Emp. Form.:
C24H26O3
Mol. Mass.:
362.4614
SMILES:
CCC(Cc1ccccc1)c1cc(O)c(C(CC)c2ccccc2)c(=O)o1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1447.64
Organism:
n/a
Description:
The peptide was derivatized with biotin and fluorescein isothiocyanate at the amino and carboxy termini.
Residue:
12
Sequence:
RVSQNYPIVQNK