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Target
Beta-secretase 2
Ligand
BDBM165910
Substrate
n/a
Meas. Tech.
ELISA Assay
IC50
4±n/a nM
Citation
 Hilpert, H; Rogers-Evans, M; Rombach, D 1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors US Patent  US9067924 Publication Date 6/30/2015 
Target
Name:
Beta-secretase 2
Synonyms:
BACE2_MOUSE | Bace2 | Beta-secretase 2 (BACE2)
Type:
Enzyme
Mol. Mass.:
55787.27
Organism:
Mus musculus (Mouse)
Description:
Q9JL18
Residue:
514
Sequence:
MGALLRALLLLVLAQWLLSAVPALAPAPFTLPLQVAGATNHRASAVPGLGTPELPRADGLALALEPVRATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIEGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLLPLHCRHAPRDPEVVNDESSLVRHRWK
  
Inhibitor
Name:
BDBM165910
Synonyms:
US9067924, 4
Type:
Small organic molecule
Emp. Form.:
C18H18F2N4O3S
Mol. Mass.:
408.422
SMILES:
C[C@]1(CCS(=O)(=O)CC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |r,c:9|
Structure:
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