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Target
Maternal embryonic leucine zipper kinase
Ligand
BDBM166113
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
1.2±n/a nM
Comments
extracted
Citation
 Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent  US9067937 Publication Date 6/30/2015 
Target
Name:
Maternal embryonic leucine zipper kinase
Synonyms:
KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:
Enzyme
Mol. Mass.:
74665.45
Organism:
Homo sapiens (Human)
Description:
Q14680
Residue:
651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
  
Inhibitor
Name:
BDBM166113
Synonyms:
US9067937, 57
Type:
Small organic molecule
Emp. Form.:
C24H27N7O
Mol. Mass.:
429.5175
SMILES:
CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cnc(nc1)C#N)C(C)=O |r,wU:4.3,wD:7.10,(-.67,5,;-2,4.23,;-3.33,5,;-2,2.69,;-.67,1.93,;.67,2.69,;2,1.93,;2,.38,;.67,-.38,;-.67,.38,;3.33,-.38,;3.33,-1.93,;4.67,-2.69,;4.67,-4.23,;3.33,-5,;2,-4.23,;.67,-5,;-.67,-4.23,;-.67,-2.69,;.67,-1.93,;2,-2.69,;-2,-1.93,;-2,-.38,;-3.33,.38,;-4.67,-.38,;-4.67,-1.93,;-3.33,-2.69,;-6,.38,;-7.34,1.15,;6,-1.93,;7.34,-2.69,;6,-.38,)|
Structure:
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