Ki Summary

Reaction Details

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Target

Maternal embryonic leucine zipper kinase

Ligand

BDBM166124

Substrate

n/a

Meas. Tech.

Kinase Assay

7.4±n/a

Temperature

298.15±n/a K

IC50

2.6±n/a nM

Comments

extracted

Citation

Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015

More Info.:

Get all data from this article, Assay Method

Target

Name:

Maternal embryonic leucine zipper kinase

Synonyms:

KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)

Type:

Enzyme

Mol. Mass.:

74665.45

Organism:

Homo sapiens (Human)

Description:

Q14680

Residue:

651

Sequence:

MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV

Inhibitor

Name:

BDBM166124

Synonyms:

US9067937, 68

Type:

Small organic molecule

Emp. Form.:

C28H33ClFN5O2

Mol. Mass.:

526.045

SMILES:

CN1CCN(C[C@H]2CC[C@@H](CC2)Nc2c(cnc3ccc(nc23)-c2cc(F)c(O)c(Cl)c2)C(C)=O)CC1 |r,wU:9.12,wD:6.5,(-.09,7.46,;-.49,5.98,;.6,4.89,;.2,3.4,;-1.29,3,;-1.69,1.51,;-.6,.42,;-1,-1.06,;.09,-2.15,;1.58,-1.75,;1.98,-.27,;.89,.82,;2.67,-2.84,;2.67,-4.38,;4,-5.15,;4,-6.69,;2.67,-7.46,;1.33,-6.69,;,-7.46,;-1.33,-6.69,;-1.33,-5.15,;,-4.38,;1.33,-5.15,;-2.67,-4.38,;-4,-5.15,;-5.33,-4.38,;-6.67,-5.15,;-5.33,-2.84,;-6.67,-2.07,;-4,-2.07,;-4,-.53,;-2.67,-2.84,;5.33,-4.38,;6.67,-5.15,;5.33,-2.84,;-2.38,4.09,;-1.98,5.58,)|

Structure: