Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM167362
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7±n/a
IC50
1700±n/a nM
Comments
extracted
Citation
 Gillespie, P Benzoic acid derivatives US Patent  US9073881 Publication Date 7/7/2015 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM167362
Synonyms:
US9073881, 114
Type:
Small organic molecule
Emp. Form.:
C23H11Cl3N2O2S
Mol. Mass.:
485.77
SMILES:
OC(=O)c1cc(ccc1-c1ccc(C#N)c(Cl)c1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Structure:
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