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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM167443
Substrate/Competitorn/a
Meas. Tech.Homogenous Time-Resolved Fluorescence (HTRF) Assay
IC50 0.1±n/a nM
Citation Kim, KYAhn, JHKang, SKRhee, SDBae, MAAhn, SHKim, HYJung, WHKang, NS Sulfamide derivative having an adamantyl group and its pharmaceutically acceptable salt US Patent US9073906 Publication Date 7/7/2015
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1)
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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  Blast E-value cutoff:
BDBM167443
NameBDBM167443
Synonyms:US9073906, 128
TypeSmall organic molecule
Emp. Form.C23H29Cl3N4O4S
Mol. Mass.563.925
SMILESCC1CCN(c2c(Cl)cc(Cl)cc2Cl)S(=O)(=O)N1CC(=O)NC1C2CC3CC1CC(C3)(C2)C(N)=O |TLB:21:22:24:29.30.31,21:22:29.28.31:24.25.26,32:29:24:22.27.26,THB:30:29:22:24.25.26,30:25:22:29.28.31,28:29:24:22.27.26,28:27:24:29.30.31,(.07,1.54,;-1.26,.77,;-2.6,1.54,;-3.93,.77,;-3.93,-.77,;-5.27,-1.54,;-6.6,-.77,;-6.6,.77,;-7.93,-1.54,;-7.93,-3.08,;-9.27,-3.85,;-6.6,-3.85,;-5.27,-3.08,;-3.93,-3.85,;-2.6,-1.54,;-3.37,-2.88,;-1.83,-2.88,;-1.26,-.77,;.07,-1.54,;1.4,-.77,;1.4,.77,;2.74,-1.54,;4.07,-.77,;4.39,1.28,;3.99,2.77,;5.08,3.85,;4.65,2.53,;5.25,.21,;6.59,-.13,;6.96,1.97,;6.56,3.45,;5.87,.88,;8.5,1.97,;9.27,3.3,;9.27,.63,)|
Structure
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