Target
11-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM167432
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence (HTRF) Assay
IC50
>10000±n/a nM
Citation
 Kim, KYAhn, JHKang, SKRhee, SDBae, MAAhn, SHKim, HYJung, WHKang, NS Sulfamide derivative having an adamantyl group and its pharmaceutically acceptable salt US Patent  US9073906 Publication Date 7/7/2015 
Target
Name:
11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3
Type:
Enzyme
Mol. Mass.:
44141.72
Organism:
Homo sapiens (Human)
Description:
Purified recombinant human 11beta-HSD2.
Residue:
405
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
  
Inhibitor
Name:
BDBM167432
Synonyms:
US9073906, 14
Type:
Small organic molecule
Emp. Form.:
C22H30FN3O3S
Mol. Mass.:
435.555
SMILES:
Fc1ccccc1CN1CCCN(CC(=O)NC2C3CC4CC(C3)CC2C4)S1(=O)=O |TLB:16:17:19:22.21.23,THB:16:17:22.24.23:19.20.26,21:22:17:19.20.26,21:20:17:22.24.23,24:22:19:17.25.26,24:25:19:22.21.23,(-6.47,-3.52,;-6.47,-1.98,;-7.81,-1.21,;-7.81,.33,;-6.47,1.1,;-5.14,.33,;-5.14,-1.21,;-3.8,-1.98,;-2.47,-1.21,;-2.47,.33,;-1.14,1.1,;.2,.33,;.2,-1.21,;1.53,-1.98,;2.86,-1.21,;2.86,.33,;4.2,-1.98,;5.53,-1.21,;5.32,.85,;4.56,2.19,;5.34,3.52,;6.88,3.51,;7.64,2.17,;6.86,.84,;7.81,.05,;6.43,.04,;5.26,2.13,;-1.14,-1.98,;-1.14,-3.52,;-2.47,-2.75,)|
Structure:
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