Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 3
Ligand
BDBM287929
Substrate
n/a
Meas. Tech.
Vasoreactivity in Rat Mesenteric Arteries In Vitro
EC50
>50000±n/a nM
Citation
 Selwood, D; Hobbs, A Agents for use in the treatment of cardiovascular and inflammatory diseases structurally based on 4(1 H)-quinolone US Patent  US10087144 Publication Date 10/2/2018 
Target
Name:
Atrial natriuretic peptide receptor 3
Synonyms:
ANP-C | ANPR-C | ANPRC | ANPRC_MOUSE | Atrial natriuretic peptide C-type receptor | Atrial natriuretic peptide clearance receptor | Atrial natriuretic peptide receptor 3 | Atrial natriuretic peptide receptor C | EF-2 | NPR-C | Npr3
Type:
PROTEIN
Mol. Mass.:
59812.13
Organism:
Mus musculus
Description:
ChEMBL_35004
Residue:
536
Sequence:
MRSLLLFTFSACVLLARVLLAGGASSGAGDTRPGSRRRAREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWRRGDKHDSEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFQMRSNVKYPWGPLKLRLDETRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNQQEESNIGKHRELREDSIRSHFSVA
  
Inhibitor
Name:
BDBM287929
Synonyms:
US10087144, Compound 188
Type:
Small organic molecule
Emp. Form.:
C23H23BrN2O4
Mol. Mass.:
471.344
SMILES:
CC(C)CC(NC(=O)c1cn(Cc2ccccc2)c2ccc(Br)cc2c1=O)C(O)=O
Structure:
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