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Target
Oxysterols receptor LXR-alpha
Ligand
BDBM168118
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Temperature
298.15±n/a K
Ki
>3330±n/a nM
Comments
extracted
Citation
 Leftheris, K; Zhuang, L Liver X receptor modulators US Patent  US9073931 Publication Date 7/7/2015 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM168118
Synonyms:
US9073931, E25b
Type:
Small organic molecule
Emp. Form.:
C20H22F3N5O3S
Mol. Mass.:
469.481
SMILES:
CC(C)[C@@H]1N(CCn2c1nc1ccc(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F |r|
Structure:
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