Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM172754
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.4±n/a
IC50
59±n/a nM
Comments
extracted
Citation
 van Duzer, JH; Mazitschek, R Selective HDAC3 inhibitors US Patent  US9096549 Publication Date 8/4/2015 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM172754
Synonyms:
US9096549, A
Type:
Small organic molecule
Emp. Form.:
C23H24FN5O
Mol. Mass.:
405.468
SMILES:
Nc1ccc(F)cc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1
Structure:
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