Reaction Details Report a problem with these data
Target
Urease subunit alpha
Ligand
BDBM173599
Substrate
n/a
Meas. Tech.
Urease Inhibition Assay
pH
7±n/a
IC50
6.892e+4± 2e+1 nM
Comments
extracted
Citation
 Rahim, F; Zaman, K; Ullah, H; Taha, M; Wadood, A; Javed, MT; Rehman, W; Ashraf, M; Uddin, R; Uddin, I; Asghar, H; Khan, AA; Khan, KM Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents. Bioorg Chem 63:123-31 (2015) [PubMed]  Article 
Target
Name:
Urease subunit alpha
Synonyms:
URE1_SPOPA | Urea Amidohydrolase Subunit alpha | Urease | ureC
Type:
Enzyme Subunit
Mol. Mass.:
61384.55
Organism:
Bacillus pasteurii
Description:
n/a
Residue:
569
Sequence:
MKINRQQYAESYGPTVGDRVRLADTDLGEVEKDYYYLGDEVNFGGGKVLREGMGENGTYTRTENVLDLLLTNALILDYTGIYKADIGVKDGYIVGIGKGGNPDIMDGVTPNMIVGTATEVIAAEGKIVTAGGIDTHVHFINPDQVDVALANGITTLFGGGTGPAEGSKATTVTPGPWNIEKMLKSTEGLPINVGILGKGHGSSIAPIMEQIDAGAAGLKIHEDWGATPASIDRSLTVADEADVQVAIHSDTLNEAGFLEDTVRAINGRVIHSFHVEGAGGGHAPDIMAMAGHPNVLPSSTNPTRPFTVNTIDEHLDMLMVCHHLKQNIPEDVAFADSRIRPETIAAEDILHDLGIISMMSTDALAMGRAGEMVLRTWQTADKMKKQRGPLAEEKNGSDNFRLKRYVSKYTINPAIAQGMAHEVGSIEEGKFADLVLWEPKFFGVKADRVIKGGIIAYAQIGDPSASIPTPQPVMGRRMYGTVGDLIHDTNITFMSKSSIQQGVPAKLGLKRRIGTVKNCRNIGKKDMKWNDVTTDIDINPETYEVKVDGEVLTCEPVKELPMAQRYFLF
  
Inhibitor
Name:
BDBM173599
Synonyms:
(Z)-2-((Z)-(4-(Dimethyl amino)benzylodine)hydrazono)thiazolidine-4-one (12)
Type:
Small organic molecule
Emp. Form.:
C18H17N3O3S
Mol. Mass.:
355.411
SMILES:
COc1cc(\C=N/N=C2\NC(=O)CS2)ccc1OCc1ccccc1
Structure:
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