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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM175116
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
7±n/a nM
Citation
 Dvorak, CA; Shireman, BT Substituted piperidine compounds and their use as orexin receptor modulators US Patent  US9115117 Publication Date 8/25/2015 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:
Protein
Mol. Mass.:
46817.55
Organism:
Rattus norvegicus (Rat)
Description:
P56718
Residue:
416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
  
Inhibitor
Name:
BDBM175116
Synonyms:
US9115117, 18 | US9115117, 87 | US9611251, 87
Type:
Small organic molecule
Emp. Form.:
C21H22F3N7O
Mol. Mass.:
445.4409
SMILES:
C[C@H]1[C@@H](CCCN1C(=O)c1nc(C)ccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F |r|
Structure:
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