Reaction Details Report a problem with these data
Target
Prostaglandin G/H synthase 2 [E165G]
Ligand
BDBM175285
Substrate
n/a
Meas. Tech.
In vitro Cyclooxygenase Inhibition Assay
IC50
2.3e+3±n/a nM
Citation
 Abdellatif, KR; Abdelgawad, MA; Elshemy, HA; Alsayed, SS Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile. Bioorg Chem 64:1-12 (2016) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 2 [E165G]
Synonyms:
COX2 | Cyclooxygenase-2 (COX-2) | PGH2_HUMAN | PTGS2
Type:
Protein
Mol. Mass.:
68932.84
Organism:
Homo sapiens (Human)
Description:
P35354[E165G]
Residue:
604
Sequence:
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVGKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
  
Inhibitor
Name:
BDBM175285
Synonyms:
3-(4-Aminosulfonylphenylamino)-2-(4-chlorophenyl)-5-methyl-4-thiazolidinone (8c)
Type:
Small organic molecule
Emp. Form.:
C16H16ClN3O3S2
Mol. Mass.:
397.9
SMILES:
CC1SC(N(Nc2ccc(cc2)S(N)(=O)=O)C1=O)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: