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Target
Protein Nef
Ligand
BDBM288166
Substrate
n/a
Meas. Tech.
Measurement of Antiviral (HIV-1) Activity
Temperature
298.15±n/a K
EC50
23.0±n/a nM
Comments
extracted
Citation
 Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent  US10087178 Publication Date 10/2/2018 
Target
Name:
Protein Nef
Synonyms:
3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef
Type:
C-terminal core protein
Mol. Mass.:
23340.47
Organism:
Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)
Description:
P03406
Residue:
206
Sequence:
MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC
  
Inhibitor
Name:
BDBM288166
Synonyms:
(1S,2S)-N-(3-chloro-2-fluoro- 5-(2-oxopyrrolidin-1- yl)benzyl)-9'-hydroxy-2- (methoxymethyl)-2'-methyl- 1',8'-dioxo-1',2',3',8'- tetrahydrospiro[cyclopropane- 1,4'-pyrido[1,2-a]pyrazine]- 7'-carboxamide | US10087178, Example T34
Type:
Small organic molecule
Emp. Form.:
C25H26ClFN4O6
Mol. Mass.:
532.949
SMILES:
COC[C@H]1C[C@@]11CN(C)C(=O)c2c(O)c(=O)c(cn12)C(=O)NCc1cc(cc(Cl)c1F)N1CCCC1=O |r|
Structure:
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