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Target
Reverse transcriptase protein
Ligand
BDBM2483
Substrate
n/a
Meas. Tech.
In-vitro HIV-1 RT Screening
IC50
25±n/a nM
Citation
 Chander, S; Ashok, P; Zheng, YT; Wang, P; Raja, KS; Taneja, A; Murugesan, S Design, synthesis and in-vitro evaluation of novel tetrahydroquinoline carbamates as HIV-1 RT inhibitor and their antifungal activity. Bioorg Chem 64:66-73 (2016) [PubMed]  Article 
Target
Name:
Reverse transcriptase protein
Synonyms:
Gag-Pol polyprotein | HIV-1 Reverse transcriptase (HIV-1 RT) | Reverse Transcriptase (HIV-1 RT) | Reverse transcriptase (HIV1-RT)
Type:
Protein
Mol. Mass.:
30197.77
Organism:
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
Description:
Q9WJQ1
Residue:
259
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEEGKISRIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK
  
Inhibitor
Name:
BDBM2483
Synonyms:
(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one | CHEMBL223228 | DMP-266 | EFV | Efavirenz | Efavirenz (EFV) | L-743,726 | Sustiva
Type:
Small organic molecule
Emp. Form.:
C14H9ClF3NO2
Mol. Mass.:
315.675
SMILES:
FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r|
Structure:
Search PDB for entries with ligand similarity: