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TargetAldehyde oxidase (AO)
LigandBDBM175348
Substrate/Competitorn/a
Meas. Tech.AO Enzyme Assay
pH7±n/a
Ki 1.60e+5± 1.98e+4 nM
IC50 1.15e+5± 0 nM
Commentsextracted
Citation Siah, MFarzaei, MHAshrafi-Kooshk, MRAdibi, HArab, SSRashidi, MRKhodarahmi, R Inhibition of guinea pig aldehyde oxidase activity by different flavonoid compounds: An in vitro study. Bioorg Chem64:74-84 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldehyde oxidase (AO)
Name:Aldehyde oxidase (AO)
Synonyms:Aldehyde: O2 oxidoreductase
Type:Protein
Mol. Mass.:145280.02
Organism:Cavia porcellus (Guinea pig)
Description:H9TB17
Residue:1332
Sequence:
MEPSTLYFYVNGRRVTEKNVDPETMLLPYLGRNLRLTGTKYGCGGGGCGACTVMVSRYDR
GTGQIRHYPACACLTPLCSLHGAAVTTVEGVGSTRTRLHPVQERIAKSHGTQCGFCTPGM
VMSLYALLRSHPQPSEEQLLEALAGNLCRCTGYRPILDAGKTFCKTSGCCQSKENGVCCL
DQGVNGVQEAEGEQTSQELCSEEEFVPLDPTQELIFPPELMILAQKQPQKSRVFTGDRVT
WISPVTLKDLLEAKAKNPRAPVVMGNTSVGPEMKFKGVFHPVIISPDGIEELSVIKQGNE
GLTLGAGLSLAQVQDVLADVVQQLPEEKTQTLCALLKQLRTLAGSQIRNMASLGGHIMSR
HLDSDLNPVLAAASCTLHVPSQEGDRQIPLDEHFLSRSPSADLRPQEVLLSVTIPYSRKW
EFVSAFRQAQRKRSARAIVNVGMRVFFGAGDGVISELCILYGGVGPAIVCATDACRKLVG
RHWTEEMLDEACRLVLGEVAIPGAAPGGRVEFRRTLLVSFLFRFYLQVSQSLSRMDPGRY
PSLVGKYESALEDLCLGHHQRTFELQSADAKQLPQDPIGRPIMHLSGIKHTTGEAIYCDD
MPLVDRELSLAFVTSSRAHAAILSMDLSEALSLPGVVDIVTAEHLGDANSFAKETLLATD
KVLCVGHLVCAVIADSEVQAKRAAEKVKIVYQDLEPLILTIEEAIQHDSFFETERKLESG
DVAEAFRTAEQVLEGSIHMGGQEHFYMETQSMLAVPKGEDQEIDLYVSTQFPTYIQEIVA
STLKLPVNKVMCHVRRVGGAFGGKVGKTAILAAITAFAALKHCRAVRCILERGEDMLITG
GRHPYLGKYKVGFRNNGQVVALDMEHYSNAGSTLDESLMVVEMGLLKMENAYKFPNLRCR
GHACKTNLPSNTALRGFGFPQSGLITEACIVEVAARCGLSPEEVREVNMYRGTEQTHYGQ
EIHTQRLAQCWSECKAKATFSLRRAAVDRFNAGSPWKKRGLAMVPLKFPVGLGSVAMGQA
AALVHVYLDGSVLLTHGGIEMGQGVHTKMIQVVSRELKMPMANVHLRGTSTETVPNANVS
GGSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKEWAQAAFDQSISLSAIGYFRGYD
ADMDWEKGKGHPFEYFVYGAACSEVEIDCLTGNHKNIRTDIVMDVGRSINPALDLGQVEG
AFIQGMGLYTSEELKYGPQGALYTRGPDQYKIPAVCDVPAELHVFFLPPSKNSNTLYSSK
GLGESGVFLGCSVLFAIWDAVSAARRERGLPGTLALSCPLTPEKIRMACEDRFTKMIPRD
TPGSYVPWDVVV
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  Blast E-value cutoff:
BDBM175348
NameBDBM175348
Synonyms:2',5'-di-Hydroxy Benzofuranone (2',5'-(OH)2) | 6-Hydroxy-2-(2',5'-dihydroxybenzylidene)benzofuran-3(2H) one
TypeSmall organic molecule
Emp. Form.C8H6O4
Mol. Mass.166.1308
SMILESOC1Oc2ccc(O)cc2C1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a