Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Lysosomal acid glucosylceramidase
Ligand
BDBM175516
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
4.5±n/a
Ki
116390±25920 nM
IC50
280070±62550 nM
EC50
65600±15700 nM
Comments
extracted
Citation
Wustman, BA Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase US Patent US9119845 Publication Date 9/1/2015 More Info.:
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1
Type:
Enzyme
Mol. Mass.:
57628.24
Organism:
Mus musculus (Mouse)
Description:
P17439
Residue:
515
Sequence:
MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
Inhibitor
Name:
BDBM175516
Synonyms:
US9119845, 17
Type:
Small organic molecule
Emp. Form.:
C11H17NO4
Mol. Mass.:
227.257
SMILES:
OC[C@@H]1[C@@H](O)[C@H](O)CCN1Cc1ccco1 |r|
Structure:
