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Target
Isoform 2 of Vascular endothelial growth factor receptor 3 (Short) 98-1298]
Ligand
BDBM176594
Substrate
n/a
Meas. Tech.
Biochemical Assay
pH
7.4±n/a
IC50
1176±n/a nM
Comments
extracted
Citation
 Holmes, IP; Bergman, Y; Lunniss, GE; Nikac, M; Chol, N; Hemley, CF; Walker, SR; Foitzik, RC; Ganame, D; Lessene, R Selective FAK inhibitors US Patent  US9120761 Publication Date 9/1/2015 
Target
Name:
Isoform 2 of Vascular endothelial growth factor receptor 3 (Short) 98-1298]
Synonyms:
FLT4 | VEGFR3 | VEGFR3 cytoplasmic domain | VGFR3_HUMAN | Vascular endothelial growth factor receptor 3 (Short) [798-1298]
Type:
n/a
Mol. Mass.:
56228.39
Organism:
Homo sapiens (Human)
Description:
P35916-1[798-1298]
Residue:
501
Sequence:
CNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFR
  
Inhibitor
Name:
BDBM176594
Synonyms:
US9120761, 8
Type:
Small organic molecule
Emp. Form.:
C28H32F3N5O
Mol. Mass.:
511.5818
SMILES:
CCc1cc(ccc1Nc1ncc(c(CCc2ccccc2CC(N)=O)n1)C(F)(F)F)C1CCNCC1
Structure:
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