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Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM50431165
Substrate
n/a
Meas. Tech.
alpha-Glucosidase Inhibition Assay
pH
6.8±n/a
IC50
3.466e+4± 2.8e+2 nM
Comments
extracted
Citation
 Imran, S; Taha, M; Ismail, NH; Kashif, SM; Rahim, F; Jamil, W; Wahab, H; Khan, KM Synthesis, In vitro and Docking Studies of New Flavone Ethers as a-Glucosidase Inhibitors. Chem Biol Drug Des 87:361-73 (2016) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM50431165
Synonyms:
2-(3-hydroxyphenyl)-4H-chromen-4-one (2) | CHEMBL147552 | NSC-22356
Type:
Small organic molecule
Emp. Form.:
C15H10O3
Mol. Mass.:
238.2381
SMILES:
Oc1cccc(c1)-c1cc(=O)c2ccccc2o1
Structure:
Search PDB for entries with ligand similarity: